Nolvadex is a non-steroid anti-estrogen which competitively inhibits estrogen receptors in the target organs and tumors in them. Mechanism of its action is not completely investigated though it is known that a complex of Nolvadex with the receptor and cofactor appears and than it is transferred to the cell nucleus preventing hypertrophy of the cells which depend on regulation by estrogen. The effect of the drug can last for several weeks after a single dose. Nolvadex is able to induce ovulation in women, stimulation of production of gonadotropic hormones from the pituitary. In men with oligospermia it increases concentration of luteinizing hormone and follicle-stimulating hormone, testosterone and estrogen in the blood serum. Nolvadex is used for treating breast cancer in women and in men (especially after castration) and also when it has spread to other parts of the body, kidney cancer, melanomas and sarcomas of soft tissues with estrogen receptors, the ovarian cancer.
Dosage and direction:Take exactly as recommended by your physician as the dosage depends on your condition. Long treatment (about 2 years) is recommended. Take this medication with food and a large glass of water as a single dose or divide it in two (taken in the morning and in the evening), do not chew or crush them.
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